Ketamine for Depression Treatment

New Depression Treatment in Greencastle, IN, Helps Patients Get Relief Fast

Depression can sap the meaning out of life. When a person feels tired, sad, and unable to enjoy parts of life they’re used to, carrying on becomes a struggle.

Ketamine infusion therapy can relieve the symptoms of depression quickly for many patients, instead of the weeks a lot of antidepressants can take. While each patient’s results can differ, 75% find relief through ketamine infusion therapy.

Ketamine has been found to be extremely effective in helping those who are treatment-resistant and have not had success with other medications or therapies.

How Does Ketamine Help Treat Depression?

The current understanding of ketamine’s function is as a non-competitive NMDA antagonist, specifically in the lateral habenula. (This is a different pathway than other psychiatric drugs, such as SSRIs, SNRIs, lamotrigine, antipsychotics, benzodiazepines, etc.)

In depression, the wiry receptors on neurons that permit signal transmission may recede, and the amygdala and hippocampus (both of which regulate mood) may lose mass. Research has shown that ketamine can trigger neural growth within days (and sometimes hours).

Another theory is that ketamine breaks habitual thought patterns that underpin mood and behavior, creating a chance for learning new, healthier habits of thought. There is no current consensus on the mode of action, and other mechanisms may be found central to ketamine’s effects.

Ketamine strengthens brain cells

Ketamine strengthens connections between brain cells. Compared with a control, a rat neuron (red) treated with ketamine has grown more dendritic spines (shown by yellow arrows).


Your brain before and after ketamine treatment for depression

The picture above shows the blood flow in a non-depressed brain *uniform on both sides and lots of yellow areas showing good blood flow, in contrast, the brain on the left shows large blue areas where blood flow, and therefore brain activity, is low.

How Do You Know If You're Depressed?

There are many signs and symptoms of depression, and it can vary from person to person.

Sustained bouts of sadness are the most common symptom signaling depression. While some people may experience debilitating sadness that involves crying and inertia, others may have simply experienced a lack of motivation due to an inability to find enjoyment broadly.

During these periods, a person may lose interest in everyday activities and have difficulty maintaining relationships. As it persists, those suffering from depression tend to fall deeper and deeper into isolation. They may stop bathing or brushing their teeth and let their home accumulate dirty dishes and filth.

When To Seek Help for Your Depression

Some people have only mild symptoms that stay manageable. While these people still need treatment, their lives are usually not completely disrupted. The following signs may mean it’s time to seek help:

  • Irregular sleep habits, like sleeping all-day
  • Isolation from friends, family, and new acquaintances
  • Self-harm
  • Substance abuse and other harmful forms of self-medication
  • Frequent talk or thoughts regarding suicide

Potential Benefits of Ketamine Treatment

  • Rapid onset of action: ketamine can provide rapid symptom relief within hours or even minutes of administration, while other antidepressants can take several weeks to start working.

  • Effectiveness in treatment-resistant depression: ketamine has been found to be effective in treating depression in individuals who have not responded to other treatments.

  • Low risk of side effects: ketamine has a low risk of side effects compared to other antidepressants, and the side effects that do occur are generally mild and short-lived.

  • Potential to improve cognitive function: some research suggests that ketamine may improve cognitive function, including memory and executive function, in individuals with depression.

Discover How Ketamine Therapy Can Help You

If you or someone you know is dealing with treatment-resistant depression and has been unable to get the relief you need utilizing conventional medications and therapies, then you might want to consider ketamine infusion therapy. Contact KetaKlarity to learn more about how ketamine treatment for depression can help you take back control of your life and your happiness.

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